Peer-Reviewed Articles
2019
36. Abdolvand N., Tostoes R., Raimes W., Kumar V., Szita N., Veraitch F. (2019) Long‐Term Retinal Differentiation of Human Induced Pluripotent Stem Cells in a Continuously Perfused Microfluidic Culture Device, Biotechnology Journal, 14(3), 1800323, doi 10.1002/biot.201800323
35. Forbesa N., Hussaina M.T., Briuglia, M.L., Edwards, D.E., Ter Horst, J.H., Szita, N., Perrie Y. (2019) Rapid and scale-independent microfluidic manufacture of liposomes entrapping protein incorporating in-line purification and at-line size monitoring, International Journal of Pharmaceutics, 556, 68-81. doi 10.1016/j.ijpharm.2018.11.060
34. Marques, M.P.C., Boyd, A.S., Polizzi, K., Szita, N. (2019) Microfluidic devices towards personalized health and wellbeing, J Chem Technol Biotechnol, doi 10.1002/jctb.6009
33. Lladó Maldonado, S., Krull, J., Rasch, P., Panjan, P., Sesay, A.M., Marques, M.P.C., Szita, N., Krull, R., (2019) Application of a multiphase microreactor chemostat for the determination of reaction kinetics of Staphylococcus carnosus, Bioprocess and Biosystems Engineering, doi.org/10.1007/s00449-019-02095-9
36. Abdolvand N., Tostoes R., Raimes W., Kumar V., Szita N., Veraitch F. (2019) Long‐Term Retinal Differentiation of Human Induced Pluripotent Stem Cells in a Continuously Perfused Microfluidic Culture Device, Biotechnology Journal, 14(3), 1800323, doi 10.1002/biot.201800323
35. Forbesa N., Hussaina M.T., Briuglia, M.L., Edwards, D.E., Ter Horst, J.H., Szita, N., Perrie Y. (2019) Rapid and scale-independent microfluidic manufacture of liposomes entrapping protein incorporating in-line purification and at-line size monitoring, International Journal of Pharmaceutics, 556, 68-81. doi 10.1016/j.ijpharm.2018.11.060
34. Marques, M.P.C., Boyd, A.S., Polizzi, K., Szita, N. (2019) Microfluidic devices towards personalized health and wellbeing, J Chem Technol Biotechnol, doi 10.1002/jctb.6009
33. Lladó Maldonado, S., Krull, J., Rasch, P., Panjan, P., Sesay, A.M., Marques, M.P.C., Szita, N., Krull, R., (2019) Application of a multiphase microreactor chemostat for the determination of reaction kinetics of Staphylococcus carnosus, Bioprocess and Biosystems Engineering, doi.org/10.1007/s00449-019-02095-9
2018
32. Abdolvand, N., Tostoes, R., Raimes, W., Kumar, V., Szita, N., Veraitch, F., (2018) Long‐term Retinal Differentiation of Human Induced Pluripotent Stem Cells in a Continuously Perfused Microfluidic Culture Device, Biotechnology Journal, doi.org/10.1002/biot.201800323
32. Abdolvand, N., Tostoes, R., Raimes, W., Kumar, V., Szita, N., Veraitch, F., (2018) Long‐term Retinal Differentiation of Human Induced Pluripotent Stem Cells in a Continuously Perfused Microfluidic Culture Device, Biotechnology Journal, doi.org/10.1002/biot.201800323
31. Radhakrishnan, A.N.P., Marques, M.P.C., Davies, M.J., O'Sullivan, B., Bracewell, D.G., Szita, N. (2018) Flocculation on a chip: a novel screening approach to determine floc growth rates and select flocculating agents, Lab on a Chip, 2018, DOI: 10.1039/C7LC00793K
30. Kulsharova, G., Dimov, N.G., Marques, M.P.C., Szita, N., Baganz, F. (2018) Simplified immobilisation method for histidine-tagged enzymes in poly(methyl methacrylate) microfluidic devices, New Biotechnology doi.org/10.1016/j.nbt.2017.12.004
2017
29. Marques, M.P.C., Szita, N., (2017) Bioprocess Microfluidics: Applying Microfluidic Devices for Bioprocessing, Current Opinion Chemical Engineering, 18, 61-68
29. Marques, M.P.C., Szita, N., (2017) Bioprocess Microfluidics: Applying Microfluidic Devices for Bioprocessing, Current Opinion Chemical Engineering, 18, 61-68
28. Gruber, P., Carvalho, F., Marques, M.P.C., O’Sullivan, B., Subrizi, F., Dobrijevic, D., Ward, J., Hailes, H.C., Fernandes, P., Wohlgemuth, R., Baganz, F., Szita, N., (2017) Enzymatic synthesis of chiral amino-alcohols by coupling transketolase and transaminase-catalyzed reactions in a cascading continuous-flow microreactor system, Biotechnology and Bioengineering, doi: 10.1002/bit.26470
27. Dimov, N, Kastner, E., Hussain, M., Perrie, Y., Szita, N. (2017) Formation and purification of tailored liposomes for drug delivery using a module-based micro continuous-flow system Scientific Reports doi:10.1038/s41598-017-11533-1
26. Gruber, P., Marques, M,P.C., Szita, N., Mayr T (2017) Integration and application of optical chemical sensors in microbioreactors. Lab Chip, 17, 2693–2712
25. Gruber, P., Marques, M,P.C., O'Sullivan, B., Baganz, F., Wohlgemuth, R., Szita, N. (2017) Conscious coupling: the challenges and opportunities of cascading enzymatic microreactors. Biotechnology Journal doi::10.1002/biot.201700030
24. Gruber, P., Marques, M,P.C., Sulzer, P., Wohlgemuth, R., Mayr, T., Baganz, F., Szita, N. (2017) Real-time monitoring of industrially relevant reactions in a microfluidics side entry reactor (μSER) shows potential for pH control. Biotechnology Journal doi::10.1002/biot.201600475
2016
23. Raimes, W., Rubi, M., Super, A., Marques, M. P. C., Veratich, F., Szita, N. (2016) Transfection in perfused microfluidic cell culture device: A case study Process Biochemistry doi:10.1016/j.procbio.2016.09.006
23. Raimes, W., Rubi, M., Super, A., Marques, M. P. C., Veratich, F., Szita, N. (2016) Transfection in perfused microfluidic cell culture device: A case study Process Biochemistry doi:10.1016/j.procbio.2016.09.006
22. Super, A., Jaccard, N., Marques, M, P,C., . Macown, R, J., Griffin, L, D., Veratich, F, S., Szita, N. (2016) Real-time monitoring of specific oxygen uptake rates of embryonic stem cells in a microfluidic cell culture device. Biotechnology Journal doi:10.1002/biot.201500479
21. Kirk, T. V., Marques, M. P. C., Radhakrishnan, A. N. P., & Szita, N. (2016) Quantification of the oxygen uptake rate in a dissolved oxygen controlled oscillating jet-driven microbioreactor. Journal of Chemical Technology and Biotechnology. doi:10.1002/jctb.4833
2015
20. Tan, C. K., Davies, M. J., McCluskey, D. K., Munro, I. R., Nweke, M. C., Tracey, M. C., & Szita, N. (2015) Electromagnetic stirring in a microbioreactor with non-conventional chamber morphology and implementation of multiplexed mixing. Journal of Chemical Technology and Biotechnology, 90 (10), 1927-1936. doi:10.1002/jctb.4762
19. Thwaites, J.W., Ruban, L., Mason, C., Dalby, P., Habib, N., Jaccard, N., Szita N. & Wall I. (2015) Influence of Initial Seeding Density on Gene Expression during Neuronal Priming. Journal of Bioprocessing & Biotechniques, 05 (01). doi:10.4172/2155-9821.1000195
18. Jaccard, N., Szita, N., & Griffin, L. D. (2015). Segmentation of phase contrast microscopy images based on multi-scale local basic image features histograms. Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization, 1-9. doi:10.1080/21681163.2015.1016243
2014
17. Jaccard, N., Macown, R. J., Super, A., Griffin, L. D., Veraitch, F. S., & Szita, N. (2014). Automated and online characterization of adherent cell culture growth in a microfabricated bioreactor. J Lab Autom, 19 (5), 437-443. doi:10.1177/2211068214529288
16. Jaccard, N., Griffin, L. D., Keser, A., Macown, R. J., Super, A., Veraitch, F. S., & Szita, N. (2014). Automated method for the rapid and precise estimation of adherent cell culture characteristics from phase contrast microscopy images. Biotech Bioeng, 111 (3), 504-517. doi:10.1002/bit.25115
15. Reichen, M., Super, A. M. C., Davies, M. J., Macown, R. J., O'Sullivan, B., Kirk, T. V., . . . Szita, N. (2014). Characterisation of an adhesive-free packaging system for polymeric microfluidic biochemical devices and reactors. Chem Biochem Eng Q, 28 (2), 189-202. doi:10.15255/CABEQ.2014.1937
14. Macown, R. J., Veraitch, F. S., & Szita, N. (2014). Robust, microfabricated culture devices with improved control over the soluble microenvironment for the culture of embryonic stem cells. Biotechnology Journal, 9 (6), 805-813. doi:10.1002/biot.201300245
2013
13. Halim, A. A., Szita, N., & Baganz, F. (2013). Characterization and multi-step transketolase-ω-transaminase bioconversions in an immobilized enzyme microreactor (IEMR) with packed tube. J Biotechnol, 168 (4), 567-575. doi:10.1016/j.jbiotec.2013.09.001
12. Davies, M. J., Nesbeth, D. N., & Szita, N. (2013). Development of a microbioreactor 'cassette' for the cultivation of microorganisms in batch and chemostat mode. Chinica Oggi - Chemistry Today, 31 (3), 46-49.
11. Reichen, M., Veraitch, F. S., & Szita, N. (2013). Development of a multiplexed microfluidic platform for the automated cultivation of embryonic stem cells. J Lab Autom, 18 (6), 519-529. doi:10.1177/2211068213499917
10. Lawrence, J., O'Sullivan, B., Lye, G. J., Wohlgemuth, R., & Szita, N. (2013). Microfluidic multi-input reactor for biocatalytic synthesis using transketolase. Journal of Molecular Catalysis B: Enzymatic, 95 (0), 111-117. doi:10.1016/j.molcatb.2013.05.016
9. Kirk, T. V., & Szita, N. (2013). Oxygen transfer characteristics of miniaturized bioreactor systems. Biotechnol Bioeng, 110 (4), 1005-1019. doi:10.1002/bit.24824
2012
8. Reichen, M., Macown, R. J., Jaccard, N., Super, A., Ruban, L., Griffin, L., . . . Szita, N. (2012). Microfabricated modular scale-down device for regenerative medicine process development. , 7 (12), e52246. doi:10.1371/journal.pone.0052246
7. O'Sullivan, B., Al-Bahrani, H., Lawrence, J., Campos, M., Cázares, A., Baganz, F., . . . Szita, N. (2012). Modular microfluidic reactor and inline filtration system for the biocatalytic synthesis of chiral metabolites. Journal of Molecular Catalysis B: Enzymatic, 77, 1-8. doi:10.1016/j.molcatb.2011.12.010
2011
6. Fernandes, R. L., Nierychlo, M., Lundin, L., Pedersen, A. E., Puentes Tellez, P. E., Dutta, A., . . . Gernaey, K. V. (2011). Experimental methods and modeling techniques for description of cell population heterogeneity. Biotechnol Adv, 29 (6), 575-599. doi:10.1016/j.biotechadv.2011.03.007
5. Matosevic, S., Szita, N., & Baganz, F. (2011). Fundamentals and applications of immobilized microfluidic enzymatic reactors. J Chem Technol Biot, 86 (3), 325-334. doi:10.1002/jctb.2564
2010
4. Schaepper, D., Stocks, S. M., Szita, N., Lantz, A. E., & Gernaey, K. V. (2010). Development of a single-use microbioreactor for cultivation of microorganisms. Chemical Engineering Journal, 160 (3), 891-898. doi:10.1016/j.cej.2010.02.038
3. Szita, N., Polizzi, K., Jaccard, N., & Baganz, F. (2010). Microfluidic approaches for systems and synthetic biology. Curr Opin Biotechnol, 21 (4), 517-523. doi:10.1016/j.copbio.2010.08.002
2. Hailes, H. C., Dalby, P. A., Lye, G. J., Baganz, F., Micheletti, M., Szita, N., & Ward, J. M. (2010). α α'-Dihydroxy Ketones and 2-Amino-1,3-diols: Synthetic and Process Strategies using Biocatalysts. Current Organic Chemistry, 1883-1893.
2009
1. Schaepper, D., Alam, M. N. H. Z., Szita, N., Lantz, A. E., & Gernaey, K. V. (2009). Application of microbioreactors in fermentation process development: a review. Anal Bioanal Chem, 395 (3), 679-695. doi:10.1007/s00216-009-2955-x
2015
20. Tan, C. K., Davies, M. J., McCluskey, D. K., Munro, I. R., Nweke, M. C., Tracey, M. C., & Szita, N. (2015) Electromagnetic stirring in a microbioreactor with non-conventional chamber morphology and implementation of multiplexed mixing. Journal of Chemical Technology and Biotechnology, 90 (10), 1927-1936. doi:10.1002/jctb.4762
19. Thwaites, J.W., Ruban, L., Mason, C., Dalby, P., Habib, N., Jaccard, N., Szita N. & Wall I. (2015) Influence of Initial Seeding Density on Gene Expression during Neuronal Priming. Journal of Bioprocessing & Biotechniques, 05 (01). doi:10.4172/2155-9821.1000195
18. Jaccard, N., Szita, N., & Griffin, L. D. (2015). Segmentation of phase contrast microscopy images based on multi-scale local basic image features histograms. Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization, 1-9. doi:10.1080/21681163.2015.1016243
2014
17. Jaccard, N., Macown, R. J., Super, A., Griffin, L. D., Veraitch, F. S., & Szita, N. (2014). Automated and online characterization of adherent cell culture growth in a microfabricated bioreactor. J Lab Autom, 19 (5), 437-443. doi:10.1177/2211068214529288
16. Jaccard, N., Griffin, L. D., Keser, A., Macown, R. J., Super, A., Veraitch, F. S., & Szita, N. (2014). Automated method for the rapid and precise estimation of adherent cell culture characteristics from phase contrast microscopy images. Biotech Bioeng, 111 (3), 504-517. doi:10.1002/bit.25115
15. Reichen, M., Super, A. M. C., Davies, M. J., Macown, R. J., O'Sullivan, B., Kirk, T. V., . . . Szita, N. (2014). Characterisation of an adhesive-free packaging system for polymeric microfluidic biochemical devices and reactors. Chem Biochem Eng Q, 28 (2), 189-202. doi:10.15255/CABEQ.2014.1937
14. Macown, R. J., Veraitch, F. S., & Szita, N. (2014). Robust, microfabricated culture devices with improved control over the soluble microenvironment for the culture of embryonic stem cells. Biotechnology Journal, 9 (6), 805-813. doi:10.1002/biot.201300245
2013
13. Halim, A. A., Szita, N., & Baganz, F. (2013). Characterization and multi-step transketolase-ω-transaminase bioconversions in an immobilized enzyme microreactor (IEMR) with packed tube. J Biotechnol, 168 (4), 567-575. doi:10.1016/j.jbiotec.2013.09.001
12. Davies, M. J., Nesbeth, D. N., & Szita, N. (2013). Development of a microbioreactor 'cassette' for the cultivation of microorganisms in batch and chemostat mode. Chinica Oggi - Chemistry Today, 31 (3), 46-49.
11. Reichen, M., Veraitch, F. S., & Szita, N. (2013). Development of a multiplexed microfluidic platform for the automated cultivation of embryonic stem cells. J Lab Autom, 18 (6), 519-529. doi:10.1177/2211068213499917
10. Lawrence, J., O'Sullivan, B., Lye, G. J., Wohlgemuth, R., & Szita, N. (2013). Microfluidic multi-input reactor for biocatalytic synthesis using transketolase. Journal of Molecular Catalysis B: Enzymatic, 95 (0), 111-117. doi:10.1016/j.molcatb.2013.05.016
9. Kirk, T. V., & Szita, N. (2013). Oxygen transfer characteristics of miniaturized bioreactor systems. Biotechnol Bioeng, 110 (4), 1005-1019. doi:10.1002/bit.24824
2012
8. Reichen, M., Macown, R. J., Jaccard, N., Super, A., Ruban, L., Griffin, L., . . . Szita, N. (2012). Microfabricated modular scale-down device for regenerative medicine process development. , 7 (12), e52246. doi:10.1371/journal.pone.0052246
7. O'Sullivan, B., Al-Bahrani, H., Lawrence, J., Campos, M., Cázares, A., Baganz, F., . . . Szita, N. (2012). Modular microfluidic reactor and inline filtration system for the biocatalytic synthesis of chiral metabolites. Journal of Molecular Catalysis B: Enzymatic, 77, 1-8. doi:10.1016/j.molcatb.2011.12.010
2011
6. Fernandes, R. L., Nierychlo, M., Lundin, L., Pedersen, A. E., Puentes Tellez, P. E., Dutta, A., . . . Gernaey, K. V. (2011). Experimental methods and modeling techniques for description of cell population heterogeneity. Biotechnol Adv, 29 (6), 575-599. doi:10.1016/j.biotechadv.2011.03.007
5. Matosevic, S., Szita, N., & Baganz, F. (2011). Fundamentals and applications of immobilized microfluidic enzymatic reactors. J Chem Technol Biot, 86 (3), 325-334. doi:10.1002/jctb.2564
2010
4. Schaepper, D., Stocks, S. M., Szita, N., Lantz, A. E., & Gernaey, K. V. (2010). Development of a single-use microbioreactor for cultivation of microorganisms. Chemical Engineering Journal, 160 (3), 891-898. doi:10.1016/j.cej.2010.02.038
3. Szita, N., Polizzi, K., Jaccard, N., & Baganz, F. (2010). Microfluidic approaches for systems and synthetic biology. Curr Opin Biotechnol, 21 (4), 517-523. doi:10.1016/j.copbio.2010.08.002
2. Hailes, H. C., Dalby, P. A., Lye, G. J., Baganz, F., Micheletti, M., Szita, N., & Ward, J. M. (2010). α α'-Dihydroxy Ketones and 2-Amino-1,3-diols: Synthetic and Process Strategies using Biocatalysts. Current Organic Chemistry, 1883-1893.
2009
1. Schaepper, D., Alam, M. N. H. Z., Szita, N., Lantz, A. E., & Gernaey, K. V. (2009). Application of microbioreactors in fermentation process development: a review. Anal Bioanal Chem, 395 (3), 679-695. doi:10.1007/s00216-009-2955-x